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The operate of SIK1 in tumorigenesis. SIK1 is really a tumor suppressor gene, which performs a significant regulatory job in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and affects most cancers mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may boost cancer

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